Cart
sales@molnova.com
MMK7 inhibitor 4a
CAS No. ——
MMK7 inhibitor 4a( —— )
Catalog No. M16995 CAS No. ——
MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMMK7 inhibitor 4a
-
NoteResearch use only, not for human use.
-
Brief DescriptionMMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7.
-
DescriptionMMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M; MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7; displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases; potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway; MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
TargetMEK
-
RecptorMEK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight456.51
-
Molecular FormulaC24H24N8O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name(R)-1-(3-(5-(1-(4-acetylphenyl)-1H-1,2,3-triazol-4-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.
molnova catalog
related products
-
Cobimetinib racemate
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.
-
Refametinib R enanti...
The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor.
-
Selumetinib
A highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.
